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PET tracers targeting transferrin receptors underperform in diffuse axonal injury, as injury boundaries are unclear and non-specific uptake occurs in perihematomal edema, resulting in signal levels below clinical detection thresholds

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In addition, REW enhanced the transport across cell layers and mucosal barriers upon intranasal delivery in mice, which was also the case for an influenza A HA-fused IgG1 Fc-fusion that was shown to protect against a deadly dose of the virus in the presence of adjuvant

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These interventions have consistently boosted survival and synaptic incorporation of grafts across different pathological contexts